Order NO. D290263
兔抗CDH1/CDH2/CDH3单克隆抗体
| 英文名 | Anti-CDH1/CDH2/CDH3 rabbit monoclonal antibody | ||
| 别名 | cadherin 1/2/3; UVO; CDHE; ECAD; LCAM; Arc-1; BCDS1; CD324; CDHN; NCAD; ACOGS; ADHD8; CD325; ARVD14; CDw325; CDHP; HJMD; PCAD | ||
| 相关类别 | 一抗 | 储存 | 冷冻（-20℃） |
| 宿主 | Rabbit | 反应种属 | Human, Mouse, Rat, Hamster |
| 标记物 | Unconjugate | 克隆类型 | rabbit monoclonal |
| 抗原 | CDH1/CDH2/CDH3 | ||
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D290263-0050 | 50 ul | 预计5日内发货 | 1400 | 1400 |
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| D290263-0100 | 100 ul | 预计5日内发货 | 2300 | 2300 |
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属性
| Background: | The CDH1 gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. The CDH2 gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. The CDH3 gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). |
| Applications: | WB, IHC, IF |
| Name of antibody: | CDH1/CDH2/CDH3 |
| Immunogen: | Synthetic peptide of human CDH1/CDH2/CDH3 |
| Full name: | cadherin 1/2/3 |
| Synonyms: | UVO; CDHE; ECAD; LCAM; Arc-1; BCDS1; CD324; CDHN; NCAD; ACOGS; ADHD8; CD325; ARVD14; CDw325; CDHP; HJMD; PCAD |
| SwissProt: | P12830/P19022/P22223 |
| IHC positive control: | Human cholangiocarcinoma |
| IHC Recommend dilution: | 50-100 |
| WB Predicted band size: | 97 kDa |
| WB Positive control: | Hela, CHO-K1, C6, Rat brain, Mouse heart, Mouse brain lysates |
| WB Recommended dilution: | 500-2000 |
| IF Positive control: | MCF-7 cells |
| IF Recommended dilution: | 50-200 |
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