The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses. [provided by RefSeq, Jul 2021]
Applications:
WB
Name of antibody:
EIF2AK2 (phospho-Thr451)
Immunogen:
Synthetic phosphopeptide corresponding to residues surrounding Thr451 of human EIF2AK2