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Order NO. D290502
兔抗EZR/RDX/MSN (phospho-Thr567/Thr564/Thr558)单克隆抗体
英文名 Anti-EZR/RDX/MSN (phospho-Thr567/Thr564/Thr558) rabbit monoclonal antibody
别名 ezrin/radixin/moesin; CVL; CVIL; VIL2; HEL-S-105; DFNB24; HEL70; IMD50
相关类别 一抗 储存 冷冻（-20℃）
宿主 Rabbit 反应种属 Human, Mouse, Rat, Hamster
标记物 Unconjugate 克隆类型 rabbit monoclonal
抗原 EZR/RDX/MSN (phospho-Thr567/Thr564/Thr558)    
编 号 包装 库存 目录价（￥） 您的价格（￥） 数 量
D290502-0050 50 ul 预计5日内发货
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D290502-0100 100 ul 预计5日内发货
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属性

Background: The cytoplasmic peripheral membrane protein encoded by the EZR gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement.
Applications: WB, IHC
Name of antibody: EZR/RDX/MSN (phospho-Thr567/Thr564/Thr558)
Immunogen: Synthetic phosphopeptide corresponding to residues surrounding Thr567/Thr564/Thr558 of human EZR/RDX/MSN
Full name: ezrin/radixin/moesin
Synonyms: CVL; CVIL; VIL2; HEL-S-105; DFNB24; HEL70; IMD50
SwissProt: P15311/P35241/P26038
IHC positive control: Human tonsil
IHC Recommend dilution: 50-100
WB Predicted band size: 69 kDa
WB Positive control: Hela, CHO-K1, C6, 3T3, 3T3+PDGF lysates
WB Recommended dilution: 500-2000
相关文档
Sample Application

  • The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using D290502(EZR/RDX/MSN (phospho-Thr567/Thr564/Thr558) Antibody) at dilution 1/50. (Original magnification: ×200)

  • Gel: 8%SDS-PAGE, Lysate: 30 μg, Lane 1-5: Hela, CHO-K1, C6, 3T3, 3T3+PDGF lysates, Primary antibody: D290502(EZR/RDX/MSN (phospho-Thr567/Thr564/Thr558) Antibody) at dilution 1/1000, Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes