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Order NO. D290601
兔抗GRIA2单克隆抗体
英文名 Anti-GRIA2 rabbit monoclonal antibody
别名 glutamate ionotropic receptor AMPA type subunit 2; GLUR2; GLURB; GluA2; HBGR2; NEDLIB; gluR-2; gluR-B; GluR-K2
相关类别 一抗 储存 冷冻(-20℃)
宿主 Rabbit 反应种属 Human, Rat
标记物 Unconjugate 克隆类型 rabbit monoclonal
抗原 GRIA2    
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D290601-0050 50 ul 预计5日内发货
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D290601-0100 100 ul 预计5日内发货
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属性

Background: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
Applications: WB, IHC
Name of antibody: GRIA2
Immunogen: Synthetic peptide of human GRIA2
Full name: glutamate ionotropic receptor AMPA type subunit 2
Synonyms: GLUR2; GLURB; GluA2; HBGR2; NEDLIB; gluR-2; gluR-B; GluR-K2
SwissProt: P42262
IHC positive control: Human breast cancer
IHC Recommend dilution: 50-100
WB Predicted band size: 99 kDa
WB Positive control: C6 lysate
WB Recommended dilution: 500-2000
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Sample Application

  • The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using D290601(GRIA2 Antibody) at dilution 1/50. (Original magnification: ×200)

  • Gel: 6%SDS-PAGE, Lysate: 30 μg, Lane: C6 lysate, Primary antibody: D290601(GRIA2 Antibody) at dilution 1/1000, Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
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