Order NO. D290601
兔抗GRIA2单克隆抗体
| 英文名 | Anti-GRIA2 rabbit monoclonal antibody | ||
| 别名 | glutamate ionotropic receptor AMPA type subunit 2; GLUR2; GLURB; GluA2; HBGR2; NEDLIB; gluR-2; gluR-B; GluR-K2 | ||
| 相关类别 | 一抗 | 储存 | 冷冻（-20℃） |
| 宿主 | Rabbit | 反应种属 | Human, Rat |
| 标记物 | Unconjugate | 克隆类型 | rabbit monoclonal |
| 抗原 | GRIA2 | ||
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D290601-0050 | 50 ul | 预计5日内发货 |
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| D290601-0100 | 100 ul | 预计5日内发货 |
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属性
| Background: | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008] |
| Applications: | WB, IHC |
| Name of antibody: | GRIA2 |
| Immunogen: | Synthetic peptide of human GRIA2 |
| Full name: | glutamate ionotropic receptor AMPA type subunit 2 |
| Synonyms: | GLUR2; GLURB; GluA2; HBGR2; NEDLIB; gluR-2; gluR-B; GluR-K2 |
| SwissProt: | P42262 |
| IHC positive control: | Human breast cancer |
| IHC Recommend dilution: | 50-100 |
| WB Predicted band size: | 99 kDa |
| WB Positive control: | C6 lysate |
| WB Recommended dilution: | 500-2000 |
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