Order NO. D291066
兔抗NTRK1/NTRK2 (phospho-Tyr490/Tyr516)单克隆抗体
| 英文名 | Anti-NTRK1/NTRK2 (phospho-Tyr490/Tyr516) rabbit monoclonal antibody | ||
| 别名 | neurotrophic receptor tyrosine kinase 1/2; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; OBHD; TRKB; DEE58; trk-B; EIEE58; GP145-TrkB | ||
| 相关类别 | 一抗 | 储存 | 冷冻（-20℃） |
| 宿主 | Rabbit | 反应种属 | Human, Mouse, Rat |
| 标记物 | Unconjugate | 克隆类型 | rabbit monoclonal |
| 抗原 | NTRK1/NTRK2 (phospho-Tyr490/Tyr516) | ||
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D291066-0050 | 50 ul | 预计5日内发货 |
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| D291066-0100 | 100 ul | 预计5日内发货 |
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属性
| WB Recommended dilution: | 500-2000 |
| WB Positive control: | K562, C6, 3T3 lysates |
| WB Predicted band size: | 92 kDa |
| SwissProt: | P04629/Q16620 |
| Synonyms: | MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; OBHD; TRKB; DEE58; trk-B; EIEE58; GP145-TrkB |
| Full name: | neurotrophic receptor tyrosine kinase 1/2 |
| Immunogen: | Synthetic phosphopeptide corresponding to residues surrounding Tyr490/Tyr516 of human NTRK1/NTRK2 |
| Name of antibody: | NTRK1/NTRK2 (phospho-Tyr490/Tyr516) |
| Applications: | WB |
| Background: | The NTRK1 gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. The NTRK2 gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. |
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