This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Applications:
WB
Name of antibody:
NTRK2 (phospho-Tyr705)
Immunogen:
Synthetic phosphopeptide corresponding to residues surrounding Tyr705 of human NTRK2
Full name:
neurotrophic receptor tyrosine kinase 2
Synonyms:
OBHD; TRKB; DEE58; trk-B; EIEE58; GP145-TrkB
SwissProt:
Q16620
WB Predicted band size:
92 kDa
WB Positive control:
Hela, A549, C6 lysates
WB Recommended dilution:
500-2000
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Sample Application
Gel: 6%SDS-PAGE, Lysate: 30 μg, Lane 1-3: Hela, A549, C6 lysates, Primary antibody: D291067(NTRK2 (phospho-Tyr705) Antibody) at dilution 1/1000, Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes