Order NO. D291110
兔抗PAX6单克隆抗体
| 英文名 | Anti-PAX6 rabbit monoclonal antibody | ||
| 别名 | paired box 6; AN; AN1; AN2; FVH1; MGDA; WAGR; ASGD5; D11S812E | ||
| 相关类别 | 一抗 | 储存 | 冷冻（-20℃） |
| 宿主 | Rabbit | 反应种属 | Human |
| 标记物 | Unconjugate | 克隆类型 | rabbit monoclonal |
| 抗原 | PAX6 | ||
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D291110-0050 | 50 ul | 预计5日内发货 |
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| D291110-0100 | 100 ul | 预计5日内发货 |
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属性
| Background: | This gene encodes paired box protein Pax-6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to a conserved paired box domain, a hallmark feature of this gene family, the encoded protein also contains a homeobox domain. Both domains are known to bind DNA and function as regulators of gene transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing results in multiple transcript variants encoding different isoforms. Interestingly, inclusion of a particular alternate coding exon has been shown to increase the length of the paired box domain and alter its DNA binding specificity. Consequently, isoforms that carry the shorter paired box domain regulate a different set of genes compared to the isoforms carrying the longer paired box domain. [provided by RefSeq, Mar 2019] |
| Applications: | WB |
| Name of antibody: | PAX6 |
| Immunogen: | Fusion protein of human PAX6 |
| Full name: | paired box 6 |
| Synonyms: | AN; AN1; AN2; FVH1; MGDA; WAGR; ASGD5; D11S812E |
| SwissProt: | P26367 |
| WB Predicted band size: | 47 kDa |
| WB Positive control: | K562, Hela lysates |
| WB Recommended dilution: | 500-2000 |
相关文档
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Sample Application
