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Order NO. D291172
兔抗PML (phospho-Ser518)单克隆抗体
| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D291172-0050 | 50 ul | 预计5日内发货 |
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| D291172-0100 | 100 ul | 预计5日内发货 |
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属性
| Background: | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| Applications: | WB, IHC |
| Name of antibody: | PML (phospho-Ser518) |
| Immunogen: | Synthetic phosphopeptide corresponding to residues surrounding Ser518 of human PML |
| Full name: | PML nuclear body scaffold |
| Synonyms: | MYL; RNF71; PP8675; TRIM19 |
| SwissProt: | P29590 |
| IHC positive control: | Human breast cancer |
| IHC Recommend dilution: | 50-100 |
| WB Predicted band size: | 98 kDa |
| WB Positive control: | A549, HL-60, U2OS lysates |
| WB Recommended dilution: | 500-2000 |
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