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Order NO. D291277
兔抗PTTG1单克隆抗体
英文名 Anti-PTTG1 rabbit monoclonal antibody
别名 PTTG1 regulator of sister chromatid separation, securin; EAP1; PTTG; ECRAR; HPTTG; TUTR1
相关类别 一抗 储存 冷冻(-20℃)
宿主 Rabbit 反应种属 Human, Mouse
标记物 Unconjugate 克隆类型 rabbit monoclonal
抗原 PTTG1    
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D291277-0050 50 ul 预计5日内发货
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D291277-0100 100 ul 预计5日内发货
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属性

Background: The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Applications: WB, IHC
Name of antibody: PTTG1
Immunogen: Synthetic peptide of human PTTG1
Full name: PTTG1 regulator of sister chromatid separation, securin
Synonyms: EAP1; PTTG; ECRAR; HPTTG; TUTR1
SwissProt: O95997
IHC positive control: Human tonsil
IHC Recommend dilution: 50-100
WB Predicted band size: 22 kDa
WB Positive control: K562, 3T3, Hela lysates
WB Recommended dilution: 500-2000
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Sample Application

  • The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using D291277(PTTG1 Antibody) at dilution 1/50. (Original magnification: ×200)

  • Gel: 12%SDS-PAGE, Lysate: 30 μg, Lane 1-3: K562, 3T3, Hela lysates, Primary antibody: D291277(PTTG1 Antibody) at dilution 1/1000, Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
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