Order NO. D291371
兔抗RUNX1/RUNX2/RUNX3单克隆抗体
| 英文名 | Anti-RUNX1/RUNX2/RUNX3 rabbit monoclonal antibody | ||
| 别名 | RUNX family transcription factor 1/2/3; AML1; CBFA2; EVI-1; AMLCR1; PEBP2aB; CBF2alpha; AML1-EVI-1; PEBP2alpha; CCD; AML3; CCD1; CLC | ||
| 相关类别 | 一抗 | 储存 | 冷冻（-20℃） |
| 宿主 | Rabbit | 反应种属 | Human, Mouse, Rat |
| 标记物 | Unconjugate | 克隆类型 | rabbit monoclonal |
| 抗原 | RUNX1/RUNX2/RUNX3 | ||
|
|||
| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D291371-0050 | 50 ul | 预计5日内发货 |
|
|
|
| D291371-0100 | 100 ul | 预计5日内发货 |
|
|
|
属性
| Background: | Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by the RUNX1 gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. The RUNX2 gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. The RUNX3 gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. |
| Applications: | WB, IHC, IF |
| Name of antibody: | RUNX1/RUNX2/RUNX3 |
| Immunogen: | Synthetic peptide of human RUNX1/RUNX2/RUNX3 |
| Full name: | RUNX family transcription factor 1/2/3 |
| Synonyms: | AML1; CBFA2; EVI-1; AMLCR1; PEBP2aB; CBF2alpha; AML1-EVI-1; PEBP2alpha; CCD; AML3; CCD1; CLCD; OSF2; CBFA1; OSF-2; PEA2aA; PEBP2aA; CBF-alpha-1; AML2; CBFA3; PEBP2aC |
| SwissProt: | Q01196/Q13950/Q13761 |
| IHC positive control: | mouse colon |
| IHC Recommend dilution: | 50-100 |
| WB Predicted band size: | 49 kDa |
| WB Positive control: | Jurkat, Rat brain, C6, CHO-K1, RAW264.7 lysates |
| WB Recommended dilution: | 500-2000 |
| IF Positive control: | Jurkat cells |
| IF Recommended dilution: | 50-200 |
相关文档
|
||||
Sample Application
