Order NO. D291665
兔抗XBP1单克隆抗体
| 英文名 | Anti-XBP1 rabbit monoclonal antibody | ||
| 别名 | X-box binding protein 1; XBP2; TREB5; XBP-1; TREB-5 | ||
| 相关类别 | 一抗 | 储存 | 冷冻（-20℃） |
| 宿主 | Rabbit | 反应种属 | Human, Mouse |
| 标记物 | Unconjugate | 克隆类型 | rabbit monoclonal |
| 抗原 | XBP1 | ||
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D291665-0050 | 50 ul | 预计5日内发货 |
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| D291665-0100 | 100 ul | 预计5日内发货 |
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属性
| Background: | This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008] |
| Applications: | WB |
| Name of antibody: | XBP1 |
| Immunogen: | Fusion protein of human XBP1 |
| Full name: | X-box binding protein 1 |
| Synonyms: | XBP2; TREB5; XBP-1; TREB-5 |
| SwissProt: | P17861 |
| WB Predicted band size: | 29 kDa |
| WB Positive control: | HL-60, U2OS, RAW264.7 lysates |
| WB Recommended dilution: | 500-2000 |
相关文档
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Sample Application
