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Order NO. D411231
PE-Cy5标记人CD95单克隆抗体
英文名 PE-Cy5-conjugated anti-human CD95 monoclonal antibody
相关类别 流式抗体 储存 冷藏（2-8℃）
宿主 Mouse 反应种属 Human
标记物 PE-Cy5 克隆类型 mouse monoclonal
抗原 CD95    
编 号 规格 库存 目录价（￥） 您的价格（￥） 数 量
D411231-0025 25 TESTS 预计7日内发货 待询价 待询价
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D411231-0100 100 TESTS 预计7日内发货 待询价 待询价
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属性

Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
Applications: FCM
Name of antibody: CD95
Full name: Fas cell surface death receptor
Synonyms: APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6
Ig class: Mouse IgG2a
FCM Recommend dosage: 5 μl/test
Laser device: Blue laser 488 nm, green laser 532 nm, yellow/green laser 561 nm
Maximum absorption/emission wavelength: 565nm/667nm
相关文档
Sample Application

  • Human peripheral blood lymphocytes stained with PE-Cy5 anti-human CD95 (colored histogram) or PE-Cy5 mouse IgG2a (gray histogram).