人NFKB1抗原（重组蛋白）,Human NFKB1 Antigen (Recombinant Protein) 生命科学产品与技术服务-生工生物工程(上海)股份有限公司

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Order NO. D620134

人NFKB1抗原（重组蛋白）

英文名	Human NFKB1 Antigen (Recombinant Protein)
相关类别	抗原	储存	冷冻（-20℃）
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编号	规格	库存	目录价（￥）	您的价格（￥）	数量
D620134-0001	1 MG	预计7日内发货	5000	5000
D620134-0050	50 UG	预计7日内发货	1250	1250
D620134-0100	100 UG	预计7日内发货	1800	1800

产品描述

概述

Fusion protein corresponding to a region derived from 769-968 amino acids of human NFKB1

属性

Full name:	nuclear factor kappa B subunit 1
Synonyms:	KBF1; EBP-1; NF-kB; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1; NF-kappabeta
Swissprot:	P19838
Gene Accession:	BC051765
Gene ID:	4790
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Research areas:	Signal Transduction, Epigenetics and Nuclear Signaling, Cancer, Immunology
Reconstitution:	Reconstitute with sterile distilled water or deionized water to 1 mg/ml
Background:	This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Aug 2020] (The background information is obtained from official databases and does not represent the product information.)

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