Order NO. D620341
TNNI3抗原（重组蛋白）
| 英文名 | TNNI3 Antigen (Recombinant Protein) | ||
| 相关类别 | 抗原 | 储存 | 冷冻（-20℃） |
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D620341-0001 | 1 MG | 预计30日内发货 |
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| D620341-0100 | 100 UG | 预计30日内发货 |
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产品描述
概述
Fusion protein corresponding to a region derived from 44-210 amino acids of human TNNI3
属性
| Full name: | troponin I3, cardiac type |
| Synonyms: | CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF |
| Swissprot: | P19429 |
| Gene Accession: | BC096165 |
| Gene ID: | 7137 |
| Purity: | >85%, as determined by Coomassie blue stained SDS-PAGE |
| Expression system: | Escherichia coli |
| Tags: | His tag C-Terminus, GST tag N-Terminus |
| Research areas: | Signal Transduction, Cardiovascular |
| Reconstitution: | Reconstitute with sterile distilled water or deionized water to 1 mg/ml |
| Background: | Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. [provided by RefSeq, Aug 2020] (The background information is obtained from official databases and does not represent the product information.) |
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