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Order NO. D620961
人MCM6抗原(重组蛋白)
英文名 Human MCM6 Antigen (Recombinant Protein)
别名 Mis5; P105MCM; MCG40308
相关类别 抗原 储存 冷冻(-20℃)
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D620961-0001 1 MG 预计30日内发货
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D620961-0100 100 UG 预计30日内发货
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产品描述

概述

Fusion protein corresponding to a region derived from 522-821 amino acids of human MCM6

属性

Full name: minichromosome maintenance complex component 6
Synonyms: Mis5; P105MCM; MCG40308
Swissprot: Q14566
Gene Accession: BC032374
Gene ID: 4175
Purity: >85%, as determined by Coomassie blue stained SDS-PAGE
Expression system: Escherichia coli
Tags: His tag C-Terminus, GST tag N-Terminus
Research areas: Epigenetics and Nuclear Signaling
Reconstitution: Reconstitute with sterile distilled water or deionized water to 1 mg/ml
Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012] (The background information is obtained from official databases and does not represent the product information.)
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Sample Application

  • Purified Human MCM6 Recombinant Protein (Catalog number: D620961) was analyzed by SDS-PAGE gel and Coomossie Blue Staining.
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