Order NO. D621214
NR0B2抗原（重组蛋白）
| 英文名 | NR0B2 Antigen (Recombinant Protein) | ||
| 别名 | SHP; SHP1 | ||
| 相关类别 | 抗原 | 储存 | 冷冻（-20℃） |
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D621214-0001 | 1 MG | 预计30日内发货 |
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产品描述
概述
Fusion protein corresponding to a region derived from 57-228 amino acids of human NR0B2
属性
| Full name: | nuclear receptor subfamily 0 group B member 2 |
| Synonyms: | SHP; SHP1 |
| Swissprot: | Q15466 |
| Gene Accession: | BC030207 |
| Gene ID: | 8431 |
| Purity: | >85%, as determined by Coomassie blue stained SDS-PAGE |
| Expression system: | Escherichia coli |
| Tags: | His tag C-Terminus, GST tag N-Terminus |
| Research areas: | Metabolism, Signal Transduction, Epigenetics and Nuclear Signaling |
| Reconstitution: | Reconstitute with sterile distilled water or deionized water to 1 mg/ml |
| Background: | The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008] (The background information is obtained from official databases and does not represent the product information.) |
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