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Order NO. D624518
人CEP57抗原（重组蛋白）
英文名 Human CEP57 Antigen (Recombinant Protein)
别名 MVA2; PIG8; TSP57
相关类别 抗原 储存 冷冻（-20℃）
编 号 规格 库存 目录价（￥） 您的价格（￥） 数 量
D624518-0001 1 MG 预计30日内发货 待询价 待询价
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D624518-0050 50 UG 预计30日内发货 待询价 待询价
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D624518-0100 100 UG 预计30日内发货 待询价 待询价
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产品描述

概述

Fusion protein corresponding to a region derived from 1-270 amino acids of human CEP57

属性

Full name: centrosomal protein 57
Synonyms: MVA2; PIG8; TSP57
Swissprot: Q86XR8-3
Gene Accession: BC039711
Gene ID: 9702
Purity: >85%, as determined by Coomassie blue stained SDS-PAGE
Expression system: Escherichia coli
Tags: His tag C-Terminus, GST tag N-Terminus
Research areas: Signal Transduction, Stem Cells
Reconstitution: Reconstitute with sterile distilled water or deionized water to 1 mg/ml
Background: This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] (The background information is obtained from official databases and does not represent the product information.)
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