Order NO. D660202
COL4A1 抗原（多肽片段）
| 英文名 | COL4A1 Antigen (Peptide fragment) | ||
| 相关类别 | 抗原 | 储存 | 冷冻（-20℃） |
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D660202-0001 | 1 MG | 预计30日内发货 |
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产品描述
概述
Synthetic peptide corresponding to a region derived from 1648-1662 amino acids of human collagen type IV alpha 1 chain
属性
| Full name | collagen type IV alpha 1 chain |
| Synonyms | BSVD; RATOR |
| Swissprot | P02462 |
| Gene Accession | NP_001836 |
| Background | This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. |
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