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Order NO. D660320
DUSP8 抗原（多肽片段）
英文名 DUSP8 Antigen (Peptide fragment)
别名 HB5, HVH8, HVH-5, C11orf81
相关类别 抗原 储存 冷冻（-20℃）
编 号 规格 库存 目录价（￥） 您的价格（￥） 数 量
D660320-0001 1 MG 预计30日内发货 待询价 待询价
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产品描述

概述

Synthetic peptide corresponding to a region derived from 2-14 amino acids of human dual specificity phosphatase 8

属性

Full name: dual specificity phosphatase 8
Synonyms: HB5, HVH8, HVH-5, C11orf81
Gene Accession: NP_004411
SwissProt: Q13202
Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.
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