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Order NO. D660502
TERT 抗原（多肽片段）
| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D660502-0001 | 1 MG | 预计30日内发货 |
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产品描述
概述
Synthetic peptide corresponding to a region derived from 1120-1132 amino acids of human telomerase reverse transcriptase
属性
| Full name: | telomerase reverse transcriptase |
| Synonyms: | TP2, TRT, EST2, TCS1, hTRT, DKCA2, DKCB4, hEST2, PFBMFT1 |
| Gene Accession: | NP_937983 |
| SwissProt: | O14746 |
| Background: | Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. |
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