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Order NO. D661550
CDKN2A 抗原（多肽片段）
英文名 CDKN2A Antigen (Peptide fragment)
相关类别 抗原 储存 冷冻（-20℃）
编 号 包装 库存 目录价（￥） 您的价格（￥） 数 量
D661550-0001 1 MG 预计30日内发货
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产品描述

概述

Synthetic peptide corresponding to a region derived from 144-156 amino acids of human cyclin-dependent kinase inhibitor 2A

属性

Full name cyclin-dependent kinase inhibitor 2A
Synonyms ARF; MLM; P14; P16; P19; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A
Swissprot P42771
Gene Accession NP_000068
Background This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.
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